FIU LAR’s team works together with FIU academic research laboratories to provide Principal Investigators or external clients with pre- clinical services. Various cell lines or animal models are available for in vivo studies. Multiple routes of dosing administration are possible and include oral, parenteral, topical, transdermal, and surgical implantation.
LAR supports both GLP and non-GLP pre-clinical services, which are customized to meet our client?s early phase drug development program, and include:
- Surgical services (e.g. kidney capsule implants, adrenalectomies, ovarioectomies, carotid and jugular catheter implantation)
- Pharmacokinetic and Pharmacodynamic studies
- Tissue distribution studies
- Dose response relationship
LAR preclinical support services include:
- IACUC Review
- Research design
- Bioanalytical support
- Report writing
FIU Animal Pathology Core Facility offers experimental pathology support to investigators using animal models to study human disease. The core facility can provide analysis and interpretation of gross and histologic findings, correlation of pathologic changes with clinical signs and clinical diagnostic results, identification and photography of representative findings for publication, and advice on investigative approaches. Also available is training in animal model analysis techniques including perfusion, necropsy, organ dissection, and tissue preparation. Training in photomicroscopy is available for investigators wishing to do their own data acquisition or analysis, and the core’s imaging and photographic equipment may be operated by qualified users by appointment. The support is offered as a collaborative effort between LAR and the Histology Core in the Department of Cellular Biology and Pharmacology at FIU, directed by Irina Agoulnik Ph.D.