Florida International University (FIU) is seeking a business partner to develop and commercialize a highly selective UV LED based Cortisol detector with ultra-high sensitivity.
Cortisol, a steroid hormone is a known biomarker for various diseases and plays a significant role in the regulation of numerous physiological processes such as blood pressure, glucose levels, carbohydrate metabolism, and in maintenance of homeostasis of the cardiovascular, immune, renal and endocrine system. A major variation in the secretion range of the hormone has been related to the sustained and prolonged exposure to environmental triggers such as stress. Hence, cortisol is considered as the major stress hormone and therefore its quantification leads to stress bio-marking. The state-of-the-art cortisol detection techniques are mostly limited to the conventional laboratory based techniques such as chromatography, radioimmunoassay, electrochemiluminescence immunoassay, enzyme-linked immunosorbent assay, surface plasmon resonance, quartz crystal microbalance and piezoelectric immunosensor. These laboratory techniques are not only expensive, laborious and time-consuming, but also they often require complex systems, assay formation complexity, large sample volume, and time-consuming incubation and separation steps, which limit its application to point-of-care (POC) application. Although several electrochemical immunosensing platforms have been developed recently for POC cortisol detection, they often require complex synthesis and fabrication steps involving the immobilizing matrix of high surface functionality, high biomolecule loading and small resistance to electron transport.
FIU inventors have developed a simple label-free, fast and cost effective sensing absorbance based optical detection technique for cortisol sensing using UV LEDs. The technology can be used in a variety of low-power electronics for wearable applications. The technology allows the incorporation of microfluidic systems into the optical sensor for enhanced POC applications. The optical sensor system can also be integrated with an appropriate specimen holder and peripheral electronics to be used with mobile electronic devices.
- Monitor cortisol level for personal health monitoring and diagnosis with POC detection
- Fast and Cost-effective
- Label free
- Portable (Point of Care applications)