Electrocardiography (ECG) Triggered Transcranial Magnetic Stimulation (TMS)

TECHNOLOGY OPPORTUNITY

Florida International University (FIU) is seeking companies interested in commercializing an ECG-triggered Transcranial Magnetic Stimulation system which reads data from existing electrocardiography (ECG) equipment to automatically compute and deliver an electromagnetic pulse to the brain at the best time and optimal intensity. Empirical evidence suggests that if the magnetic stimulus is not synchronized with the cardiac cycle, there is potential for detrimentally slowing down the heart rate. However, if the same stimulus is synchronized to select moments of the cardiac cycle, minimal or no heart rate alteration will occur. Furthermore, the integration of ECG with transcranial magnetic stimulation (TMS) allows for the precise analysis and interpretation of the state of the patient heart, the ECG, and provides a more complete assessment of a given patient.

The software of this technology can detect individual cardiac wave deflections as well as the intervals between them. This technology is capable of processing this data from the ECG for computing and delivering a prescribed intensity of magnetic stimulation at a precise time in the cardiac cycle. Therefore, such a system allows for the timely and safe delivery of the brain stimulation, all while continuously monitoring the ECG signal. The same mechanism which automates the different functions of the TMS is also able to abort the stimulation if any unwarranted effects such as abnormal cardiac rhythm or other abnormalities are observed by the ECG.

APPLICATIONS

This brain magnetic stimulation can be used for administering electromagnetic stimulations for the treatment of depression, Alzheimer’s disease, migraine headaches, autism, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), and other neurological disorders. Additionally, this technology can be used for brain mapping of the eloquent cortex for pre-surgical evaluations.

ADVANTAGES
  • Easy stimulus synchronization
  • Fully automated
  • Improves upon patient safety
  • Simultaneous ECG monitoring and delivery of magnetic stimulus
  • Useful for a wide range of neurological applications
  • Compatible with existing ECG technology
CONTACT

For additional information about this technology opportunity, please contact Elizabeth Garami at egarami@fiu.edu or by phone at 305-348-0008 and ask about record IP 1305.