Novel Functional Imaging of Photoreceptors in the Retina by Rhodopsin Mapping

A completely new approach to measure the content of rhodopsin, a quantum leap from the traditional fundus reflectometry.

TECHNOLOGY OPPORTUNITY

Florida International University (FIU) is pursuing a business partner interested in developing and commercializing a Novel Functional Imaging of Photoreceptors in the Retina by Rhodopsin Mapping. FIU inventors created four novel technologies that allow for functional imaging of the photoreceptors in the retina. The technologies can be used in the clinical setting to assess the structure and function of photoreceptors. Specifically in the diagnosing, disease staging and follow up of retinal degenerative disorders, such as hereditary retinal degeneration and age-related age macular regeneration. This technology will also be useful when creating outcome measurements for clinical trials of these diseases.

The technology relies on an Integrated Parallel Multi-Channel-Space-Time-Coded Scanning Laser Opthalmoscopy (SLO) that detects differences in optical absorption in dark and light adapted states, and a Triple-band Rhodopsin OCT which uses three separate wavelengths within the rhodopsin absorption spectrum, which obtain all the information required to calculate and reconstruct a quantitative retinal rhodopsin image with a single scan of a dark-adapted retina.

We are searching for a business partner to further develop and commercialize this novel functional imaging of photoreceptors in the retina by rhodopsin mapping as a viable alternative to existing technologies used in traditional fundus reflectometry and to exploit its scientific and business potential as a highly accurate and cost effective form of photoreceptor imaging.

APPLICATIONS

Can be used by ophthalmology clinics, pharmaceutical companies, and research laboratories for the assessment of the global and local functional status of photoreceptors in the retinas of the living subjects.

Could be used to diagnose retinal degenerative diseases, such as retinitis pigmentosa.

  • Assess photoreceptor function following retinal detachment repair, for staging retinal degenerative diseases, and to monitor the degenerative process.
  • Useful in monitoring photoreceptor loss related to dry age-related macular degeneration.
  • Useful in monitoring the visual cycle repair by gene therapy of patients of Leber congenital ameurosis caused by mutations in the RPE65 gene.
  • Future use could include the assessment of functional photoreceptors in photoreceptor regeneration either by external cell implantation, or by re-programming of existing retinal cells.
ADVANTAGES
  • Allows for accurate and objective measurement of rhodopsin content in live subjects for the assessments of functional photoreceptors
  • No existing technologies are capable of providing optical section of the retina in live subjects with the purpose of localizing rhodopsin in the retinal layers.
  • This is the first technology to provide both a local topographic rhodopsin map in a retinal B-scan image, and a 3D topographic map of rhodopsin in the retina.
  • The technology addresses the two major technical issues that current available technologies fail to address. Specifically slow scanning speed of the SLO and, the influence of absorption by rhodopsin intermediates.
  • Scanning speed is dramatically increased, directly reducing the influence of eye movement during imaging, which significantly improves the image quality
  • Much more cost effective than technologies that use multi light sources and multi detectors to achieve the same scanning speed
  • Reduction of the absorption by rhodopsin intermediates, while simultaneously decoupling the image speed and exposure time for each imaging point. These features make the technology more accurate and clinic friendly.
  • The Triple-band rhodopsin VIS-OCT is a completely new approach to measure the content of rhodopsin, a quantum leap from the traditional fundus reflectometry.
CONTACT

For additional information about this technology opportunity, please contact Elizabeth Garami at egarami@fiu.edu or by phone at 305-348-0008 and ask about record IP 1431.