Non-Silica Based Material for High-Performance Liquid Chromatography and Solid Phase Extraction

TECHNOLOGY OPPORTUNITY

Florida International University (FIU) is seeking a business partner to develop and commercialize Non-Silica Based Material for High-Performance Liquid Chromatography and Solid Phase Extraction.

Supports for reversed phase high-performance liquid chromatography (RP-HPLC) column, normal phase high-performance liquid chromatography (NP-HPLC) column, and hydrophilic interaction liquid chromatography (HILIC) column are silica particles coated with organic ligands via silane chemistry. As a result, only a very small portion of the stationary phase contributes to retention and selectivity. The currently used bonded phases for these chromatography columns suffer from a number of shortcomings: silica particles limit the loading of organic ligands, which leaves many surface silanol groups unattended on the silica surface, and results in chemical instability, particularly when using basic solvents.

FIU inventors have developed sol-gel sorbent or chromatography stationary phase comprising particles of a metal oxide gel containing polymeric segments uniformly distributed throughout the metal oxide gel. The chemical incorporation of various organic polymers into the sol-gel hybrid inorganic-organic matrix opens up the possibility of creating hundreds of novel sorbents with unique selectivity.

APPLICATIONS
  • Food, pharmaceutical, environmental, toxicological, clinical, and forensic analysis
  • Environmental remediation and antimicrobial and/or other protective coatings in food or pharmaceutical packaging
ADVANTAGES
  • Eliminates the need of using silica substrate to hold different polar functional moieties
  • Displays high resistance against high temperature, harsh chemical environment, with pH stability that can range from 1-13
  • Provides a high surface area for rapid interaction with the analyte(s)
  • Eliminates the need of solvent evaporation and sample reconstitution when used as SPE sorbents
QUESTIONS ABOUT THIS TECHNOLOGY

Call Anne-Laure “Anlo” Schmitt-Olivier at 305-348-5948 or fill out the quick contact form below.