Dynamic Fabric Phase Sorptive Extraction (DFPSE)


Florida International University (FIU) is pursuing commercial partners interested in commercializing Dynamic Fabric Phase Sorptive Extraction (DFPSE) disks, a new generation solid phase extraction disk capable of extracting target analyte(s) exhaustively from unmodified sample matrices containing high volume of matrix interferents including particles, debris, biomass, cells, tissues, proteins without employing any sample clean-up exercise.

The technology provides the process of making DFPSE disks by chemically immobilizing organic polymers or ligands on a flexible substrate resulting in an exhaustive sample preparation (cleaning/preconcentration) to accomplish high recovery of target analyte(s) in a short period of time.

DFPSE provides flexible, open, flat and easily accessible surface for rapid sorbent-analyte interaction. Since both the surfaces and inner matrix of the substrate are coated with inherently porous sol-gel hybrid materials, the accessible surface area for DFPSE media are enormous leading to a very high sample capacity.

In DFPSE, any organic solvent or solvent mixture can be used as the eluent/back-extraction solvent since the composite coatings are chemically bonded to the substrate. As a result, same sample can be analyzed in GC/HPLC/CE if a mutually compatible solvent is chosen for the back-extraction. Utilization of proper solvent for back-extraction also ensures no analyte carry-over that may hinders future extractions or compromises the quality of analytical data. Also, high enrichment factors obtained in DFPSE eliminates the necessity of time consuming solvent evaporation and sample reconstitution step.

Due to the strong covalent bonding between the hybrid coating and the substrate, the coating demonstrates high chemical stability and can be exposed to high acidic (pH 1) and basic (pH 12) environment without compromising the integrity of the extraction disk.

DFPSE allows user to use disks coated with polymers of different polarity. As a result, if the objective of the analytical scheme is to extract analytes with different polarity, multiple disks coated with different polarity can be employed. At the end, all extracted analytes can be back-extracted in the same back-extraction solvent.


Collection and preconcentration of target analytes from unmodified sample matrix of chemical, biochemical, pharmaceutical, forensic, clinical, and environmental significance.

  • Fast and highly sensitive sampling and sample preparation capability.
  • Flexible, highly reproducible, portable and easy to use.
  • Very high sample capacity translates into high break-through volume.
  • High chemical and solvent stability allows exposure to any organic solvent and aqueous solution with pH ranges of 1-12.

For additional information about this technology opportunity, please contact Elizabeth Garami at egarami@fiu.edu or by phone at 305-348-0008 and ask about record IP 1319.