Landmark-Driven Virtual Colonoscopy with Decorated Surface Mapping and Registration

A novel and effective colon flattening tool to straighten anatomical landmark curves


Florida International University (FIU) is pursuing a business partner interested in developing and commercializing Landmark-Driven Virtual Colonoscopy with Decorated Surface Mapping and Registration as an effective mapping and registration method for virtual colonoscopies and other landmark-driven applications. FIU inventors have developed a method for understanding the nature of landmark curves on a 2D domain. This method provides a canonical and straightforward view of the long, convoluted and folded tubular colon surface. This well-structured view represents both local and global geometric structures and is more accessible for reading or automatic screening than conformal views with broken features. Using the quasiconformal geometry, the proposed flattening method formulates as a quasiconformal (QC-map) where the landmarks (such as taeniae coli and flexures) are mapped to vertical and horizontal straight lines and distortion is minimized. The novel surface mapping and registration method is capable of computing optimal mapping over canonical domains with straight segments, where curve constraints become linear. Due to the linearity of harmonic mapping and the 1-form method, algorithms are easy to compute, efficient and practical.


Anatomical landmark constraints are used in computer-aided diagnosis and the detection of tumors or abnormalities such as sulci and gyri curves in brain mapping, facial symmetry curves in adolescent idiopathic scoliosis (AIS) and autism diagnosis, and taeniae coli, flexures, and haustral folds for supine-prone colon registration. Other applications include feature-aware visualization, matching, precise curve-constrained registration, and shape analysis (3D colon straightening).

  • Landmark curve distortion is minimized
  • The algorithm is easy to implement, efficient in computation, and robust and stable to handle multiple and complicated decorative landmark curves
  • Registration method automatically generates a unique and intrinsic parameter domain and provides uniformity to both surface and decorative landmark geometries
  • Can handle multiple, complicated topological surfaces and decorative landmarks

For additional information about this technology opportunity, please contact Elizabeth Garami at or by phone at 305-348-0008 and ask about record IP 1420.